2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W009713
    3,4,5-Trimethoxyphenylacetic acid
    		99.57%
    3,4,5-Trimethoxyphenylacetic acid is a metabolite of Mescaline.
    3,4,5-Trimethoxyphenylacetic acid
  • HY-135334
    ACP-5862
    		98.41%
    ACP-5862 is a major active, circulating, pyrrolidine ring-opened metabolite of Acalabrutinib with an IC50 of 5.0 nM for Bruton tyrosine kinase (BTK). ACP‐5862 is a weak time‐dependent inactivator of CYP3A4 and CYP2C8. Acalabrutinib is an orally active, irreversible, and highly selective BTK inhibitor, with an IC50 of 3 nM and EC50 of 8 nM.
    ACP-5862
  • HY-A0115
    Ramiprilat
    Ramiprilat (HOE 498 diacid), an active metabolite of Ramipril, is a potent and orally active angiotensin converting enzyme (ACE) inhibitor with a Ki value of 7 pM. Ramiprilat can be used for high blood pressure and heart failure research.
    Ramiprilat
  • HY-148375
    Abiraterone sulfate
    		98.87%
    Abiraterone sulfate is a metabolite of Abiraterone (HY-148377). Abiraterone is a potent and irreversible CYP17A1 inhibitor with antiandrogen activity.
    Abiraterone sulfate
  • HY-138627A
    AST5902 trimesylate
    		98.75%
    AST5902 trimesylate is the principal metabolite of Alflutinib (AST2818) both in vitro and in vivo. AST5902 trimesylate exerts antineoplastic activity. Alflutinib is an EGFR inhibitor.
    AST5902 trimesylate
  • HY-142122
    Imipramine N-oxide
    		99.87%
    Imipramine N-oxide is the metabolite of Imipramine. Imipramine is a tertiary amine tricyclic antidepressant.
    Imipramine N-oxide
  • HY-N8210
    Homoeriodictyol
    		99.79%
    Homoeriodictyol is a flavonoid metabolite of Eriocitrin in plasma and urine. Eriocitrin is a strong antioxidant agent.
    Homoeriodictyol
  • HY-126848
    Diclofenac acyl glucuronide
    Diclofenac acyl glucuronide (D-1-O-G) is a major bile metabolite directly involved in small intestinal ulceration in rats.
    Diclofenac acyl glucuronide
  • HY-W014993
    1,3-Dimethyluric acid
    		99.36%
    1,3-Dimethyluric acid is a product of theophylline metabolism in man. 1,3-Dimethyluric acid is one of the purine components in urinary calculi.
    1,3-Dimethyluric acid
  • HY-G0017S
    N-Desmethyl imatinib-d8
    		99.95%
    N-Desmethyl imatinib-d8 is a deuterium labeled Imatinib metabolite N-Desmethyl Imatinib.
    N-Desmethyl imatinib-d<sub>8</sub>
  • HY-100646A
    (Z)-10-Hydroxynortriptyline
    		99.72%
    (Z)-10-Hydroxynortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression.
    (Z)-10-Hydroxynortriptyline
  • HY-I0177
    Vilazodone carboxylic acid
    		98.20%
    Vilazodone carboxylic acid is a vilazodone metabolite observed in both urine (major) and plasma (minor).
    Vilazodone carboxylic acid
  • HY-W006000
    Tetrachlorocatechol
    		98.17%
    Tetrachlorocatechol is a metabolite of pentachlorophenol. Tetrachlorocatechol is one of the most toxic chlorinated catechol produced by the chlorobleaching of pulp and frequently found in the kraft pulp mill effluents.
    Tetrachlorocatechol
  • HY-145991
    Ribavirin carboxylic acid
    		99.85%
    Ribavirin carboxylic acid (TR-COOH) is a metabolite of Ribavirin (HY-B0434), Ribavirin has strong antiviral activity.
    Ribavirin carboxylic acid
  • HY-W016221
    6-Hydroxy Chlorzoxazone
    		98.10%
    6-Hydroxy Chlorzoxazone is a metabolite of Chlorzoxazone (HY-B1462). Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
    6-Hydroxy Chlorzoxazone
  • HY-135847
    Desmethyl ferroquine
    		98.02%
    Desmethyl ferroquine (SSR97213) is the active and major metabolite of Ferroquine. Ferroquine is an antimalarial. Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains.
    Desmethyl ferroquine
  • HY-114794
    Desglymidodrine
    Desglymidodrine (ST 1059), the active metabolite of Midodrine (HY-12749), is a selective α1-adrenoceptor agonist. Desglymidodrine is an effective arterial and venous vasoconstrictor and can be used to regulate blood pressure.
    Desglymidodrine
  • HY-141776S
    Omeprazole sulfide-d3
    		99.79%
    Omeprazole sulfide-d3 is the deuterium labeled Omeprazole sulfide. Omeprazole metabolite Omeprazole sulfide (Ufiprazole) is a metabolite of Omeprazole, which is a proton pump inhibitor.
    Omeprazole sulfide-d<sub>3</sub>
  • HY-N3995
    5β-Dihydrocortisol
    		99.70%
    5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis.
    5β-Dihydrocortisol
  • HY-W053507
    m-Tolylacetic acid
    		99.90%
    m-Tolylacetic acid (3-Methylbenzeneacetic acid) is a hydroaromatic dicarboxylic acids excreted in the urine as metabolite of tolueneacetic acid.
    m-Tolylacetic acid
Cat. No. Product Name / Synonyms Application Reactivity